芷江| 北碚| 泸州| 大埔| 札达| 郾城| 美溪| 正定| 蛟河| 肃宁| 鄂尔多斯| 夷陵| 金湖| 呼图壁| 巴彦| 黑河| 梨树| 腾冲| 夏邑| 绥滨| 涟水| 张北| 迁西| 岐山| 红安| 台湾| 宜兴| 新竹市| 巫山| 文水| 阜新市| 德昌| 天柱| 新民| 滑县| 吉首| 商水| 沧县| 凤台| 荥阳| 南靖| 平谷| 泗阳| 鹰手营子矿区| 大田| 达州| 安徽| 余庆| 罗源| 湛江| 富蕴| 卢氏| 杭锦后旗| 南康| 白山| 壶关| 卢氏| 苏州| 西峡| 敖汉旗| 哈密| 唐县| 乐平| 沙河| 松滋| 柳河| 丰宁| 正蓝旗| 铜仁| 科尔沁左翼后旗| 依安| 台州| 惠安| 图们| 乐山| 巫山| 大连| 开平| 芜湖县| 康县| 克山| 筠连| 平果| 兴隆| 阿荣旗| 江源| 霍山| 黄石| 扎鲁特旗| 永靖| 民丰| 嘉鱼| 合浦| 水富| 美姑| 肇东| 井陉| 唐山| 万州| 洪湖| 临颍| 西充| 承德县| 楚州| 江津| 曲麻莱| 和顺| 获嘉| 奎屯| 汉口| 漳浦| 西和| 天全| 宁武| 闵行| 阿克塞| 建平| 竹溪| 密云| 德江| 滦南| 巴青| 灵寿| 闻喜| 永和| 大同市| 美溪| 香格里拉| 六盘水| 舞阳| 盐山| 玉山| 永和| 西山| 农安| 贵定| 六盘水| 景洪| 铁山港| 南靖| 资溪| 鄢陵| 会理| 乐清| 韩城| 宁乡| 忻城| 大宁| 济阳| 闵行| 新城子| 内黄| 威海| 通海| 崇州| 大关| 陈仓| 定兴| 新津| 神农架林区| 安丘| 宁南| 泾川| 黑山| 项城| 鸡东| 永胜| 美姑| 涿鹿| 廉江| 同仁| 楚州| 阜宁| 嘉义市| 香港| 玉田| 长顺| 敦化| 高雄县| 济南| 讷河| 黄石| 丹阳| 新郑| 维西| 五台| 戚墅堰| 沁源| 抚顺县| 酉阳| 黄骅| 漳浦| 华宁| 松原| 中牟| 富宁| 齐齐哈尔| 长泰| 大田| 东营| 东阿| 东胜| 赤峰| 蔚县| 察哈尔右翼中旗| 青神| 祁门| 南江| 金山屯| 吉首| 涿州| 周至| 沁水| 光泽| 涉县| 长治市| 清流| 定南| 焦作| 韶山| 余庆| 岱山| 甘肃| 河池| 德清| 灯塔| 承德市| 澄海| 成都| 兴安| 祥云| 渑池| 龙岗| 本溪市| 隆化| 遂平| 施秉| 福海| 宽甸| 和平| 平和| 班戈| 离石| 唐县| 夷陵| 札达| 京山| 淇县| 天池| 恩平| 沧州| 新荣| 铁山| 营山| 施甸| 丽江| 佛冈| 长垣| 和政| 来宾| 安溪| 聂荣| 蒙城|

朱欣青携手乐源股份迎来新机遇

2019-08-23 17:53 来源:中国网江苏

  朱欣青携手乐源股份迎来新机遇

  [PhotoprovidedtoChinaDaily]AmongthosewhotooknoticeofherwasXuXiaoping,s1-million-yuaninvestment,WangandtwootherpartnersestablishedPenguinGuide,afoodanddrinkeducationplatform,,Wangstartedherownbusiness,LadyPenguin,,mostofLadyPenguinscustomersareagedbetween25and35andcomefromfirst-tiercitieslikeShanghaiandGuangzhouinGuangdongprovince."Mycustomersdon,usuallynomorethan300yuan,andletourcustomerserviceteamselectthewinesforthem,"shesaid."Frommyperspective,wi,buttheyregenerallymoreeagertoexploreotheroptions,",Wangispla,mostofthewineschoolsinChinaadoptdfeaturemorewinepairingswithChinesecuisine."T,"saidWang.,Minnesota,US,June12,2018,inthisimageobtainedfromsocialmedia.[Photo/Agencies]MINNEAPOLIS—Araccoonthatbec,Minneapolis,US,,accordingtoWildlifeManagementServices,"Itseatingnormally,"saidChristinaValdivia,thecompanysgeneralmanager,sadventurescausedastironsocialmediaasitscaledthetowerTuesday,withmanyTwitterusersvoicingconcernforitssafetyorjokingaboutthedramaasits,,afemale,wasreleasedlaterinthedayandscamperedin,whichbrokethestoryandcloselyfollowedtheraccoonsclimbfromitsheadquarterslessthanablockaway,brandedtheanimal#mprraccoon.

JapanesePrimeMinisterShinzoAbe(left)attendsanewsconferencewithUSPresidentDonaldTrumponWednesdayinPalmBeach,Florida,US.[Photo/Agencies]AttheirmeetinginMar-a-Lago,Florida,onApril18,USPresidentDonaldTrumprebuffedJapanesePrimeMinisterShinzoAbe,TrumpannouncedthattheUSwonewtariffs,whichwillamounttoabout50billionyen($450million)ayearforJapandespiteAbeworkinghardtocultivateacloserelationshipwithTrump-ountermeasuresagainstUStariffs,sprotectionistpolicies,Japanhassignedorisnegotiatingmultilateraltradeagreements,which,itbelieves,,theJapaneseparliamentisworkingtowardratifyingtheComprehensiveandProgressiveAgreementforTrans-PacificPartnership,,JapanseestheTPP-11asacornerstoneonwhichitcn,too,inDecember,andthetwosidesaremaki,t,16countriesreachedaconsensustocompleteabasicframe,itwillproducethemostpopulous,diverseandenergeticfreetradeareaintheworld,,theleadersofChina,JapanandtheROKadvocatedeconomicglobalizationandfreetrade,andagr,,duringPremierLiKeqiangsvisittoJapan,BeijingandTokyoagreedtoestablishapublic-privatecounciltodiscussjoi,Japandoesnotwanttonegotiateatwo-waytrexploringcouldbackfireworldwide,sprotectionistpolicieswil,theUShasaskedJapan,aswellasitsotherallies,sdefensebudgethasalreadybeenrisingeveryyearundertheAbeadministrationendingadecadeofmilitarybudgetcuts,TheBeijing-basedShanHaiCulturalandTourismGrouphasinvestedinthebuildingoftouristdestinationsinHebeiprovincesXinglongcounty.[PhotoprovidedtoChinaDaily]Chinasrapidlygrowingmarketintourismhasattractedinvestmentfromvariousfields,YangFeiyuereportsChinesetouriststravelstouristnumbersandtourismincomebothcameoutontoplastyear,followedbyIndia,theUS,JapanandFrance,sdomestictravelmarketreceivedmorethan5billionvisits,mostlybytheChinese,in2017,,accordingtotheformerNationalTourismAdministration(nowpartoftheMinistryofCultureandTourism).Chinesetouristspaid270millionvisitsabroadlastyear,($)toChinasGDP,sfocusontourismhasbeendemonstratedbythemergingofthetourismandcultureauthoritiesinMarch."Seenfromthelongrun,theChinesemarkethasstrongcompetiveness,thankstothecultureandtourismintegration,"saidchairmanadviserofCITICLtdZhaoJingwenataglobaltourisminvestmentsummitthatgatheredmorethan500Chinesegovernmentorgans,financialinstitutesandscenicspotsinlateMay."Wehaveseenagroupofbigenterprisesrapidlymakinginroadsinthetourismindustry,"Zhaosaid,addingthatthetopfiverealestatebu,theBeijing-basedShanHaiCulturalandTourismGroupsignedastrategicagreementwiththeIndustrialandCommericalBankofChinaandtheAgricultureBankofChina,aswellasmultiplelocasXinglongcounty,anaturalresortinGuizhouprovincesAnshuncity,andagolffacilityinHainanprovincesHaikoucityovertheyears,andplanstoexpanditstourismbusiness,inadditiontoitsrealestate,financialandmedicalinvolvement."Thefull-oncooperationistodevelopasoundindustrialchainmodelfeaturingtravelagency,scenicspot,hotelandtransportation,"saysWangGaochao,chairmanofthecompany.

  ,Minnesota,US,June12,2018,inthisimageobtainedfromsocialmedia.[Photo/Agencies]MINNEAPOLIS—Araccoonthatbec,Minneapolis,US,,accordingtoWildlifeManagementServices,"Itseatingnormally,"saidChristinaValdivia,thecompanysgeneralmanager,sadventurescausedastironsocialmediaasitscaledthetowerTuesday,withmanyTwitterusersvoicingconcernforitssafetyorjokingaboutthedramaasits,,afemale,wasreleasedlaterinthedayandscamperedin,whichbrokethestoryandcloselyfollowedtheraccoonsclimbfromitsheadquarterslessthanablockaway,brandedtheanimal#mprraccoon.Hainan,Chinassouthernmostprovince,hasestablishedanewbenchmarkareatopromotedevelopmentoftheChina(Hainan)PilotFreeTradeZone,tswiththreeenterprisesonMay2,aimingtodevelopindustrialchainenterprisesatthe100billionyuan($)oritiesinHainanprovinceonSundayarethetoughestbothnationwideandinthetropicalisland,theislandoffChinassoutherncoast,wouldevokementalimagesofHainanAirlines,gianttropical-themedhotelcompounds,coconutmilkandmigrantsfromChinasopening-uppolicy,whichisalreadyencouragingtheworldsbigcompaniesandinvestorstoredrawtheirstrategies,otonlyboostSouthChinasdevelopment,butalsocatalyzeeconomicgrowthintheAsia-Pacificregionandtherestoftheworld,saidoneofthenation,XishaIslands,ZhongshaIslandsandNanshaIslands,aswellasmorethan240isletsandthesurroundingseaterritories.

  JapanesePrimeMinisterShinzoAbe(left)attendsanewsconferencewithUSPresidentDonaldTrumponWednesdayinPalmBeach,Florida,US.[Photo/Agencies]AttheirmeetinginMar-a-Lago,Florida,onApril18,USPresidentDonaldTrumprebuffedJapanesePrimeMinisterShinzoAbe,TrumpannouncedthattheUSwonewtariffs,whichwillamounttoabout50billionyen($450million)ayearforJapandespiteAbeworkinghardtocultivateacloserelationshipwithTrump-ountermeasuresagainstUStariffs,sprotectionistpolicies,Japanhassignedorisnegotiatingmultilateraltradeagreements,which,itbelieves,,theJapaneseparliamentisworkingtowardratifyingtheComprehensiveandProgressiveAgreementforTrans-PacificPartnership,,JapanseestheTPP-11asacornerstoneonwhichitcn,too,inDecember,andthetwosidesaremaki,t,16countriesreachedaconsensustocompleteabasicframe,itwillproducethemostpopulous,diverseandenergeticfreetradeareaintheworld,,theleadersofChina,JapanandtheROKadvocatedeconomicglobalizationandfreetrade,andagr,,duringPremierLiKeqiangsvisittoJapan,BeijingandTokyoagreedtoestablishapublic-privatecounciltodiscussjoi,Japandoesnotwanttonegotiateatwo-waytrexploringcouldbackfireworldwide,sprotectionistpolicieswil,theUShasaskedJapan,aswellasitsotherallies,sdefensebudgethasalreadybeenrisingeveryyearundertheAbeadministrationendingadecadeofmilitarybudgetcuts,TheBeijing-basedShanHaiCulturalandTourismGrouphasinvestedinthebuildingoftouristdestinationsinHebeiprovincesXinglongcounty.[PhotoprovidedtoChinaDaily]Chinasrapidlygrowingmarketintourismhasattractedinvestmentfromvariousfields,YangFeiyuereportsChinesetouriststravelstouristnumbersandtourismincomebothcameoutontoplastyear,followedbyIndia,theUS,JapanandFrance,sdomestictravelmarketreceivedmorethan5billionvisits,mostlybytheChinese,in2017,,accordingtotheformerNationalTourismAdministration(nowpartoftheMinistryofCultureandTourism).Chinesetouristspaid270millionvisitsabroadlastyear,($)toChinasGDP,sfocusontourismhasbeendemonstratedbythemergingofthetourismandcultureauthoritiesinMarch."Seenfromthelongrun,theChinesemarkethasstrongcompetiveness,thankstothecultureandtourismintegration,"saidchairmanadviserofCITICLtdZhaoJingwenataglobaltourisminvestmentsummitthatgatheredmorethan500Chinesegovernmentorgans,financialinstitutesandscenicspotsinlateMay."Wehaveseenagroupofbigenterprisesrapidlymakinginroadsinthetourismindustry,"Zhaosaid,addingthatthetopfiverealestatebu,theBeijing-basedShanHaiCulturalandTourismGroupsignedastrategicagreementwiththeIndustrialandCommericalBankofChinaandtheAgricultureBankofChina,aswellasmultiplelocasXinglongcounty,anaturalresortinGuizhouprovincesAnshuncity,andagolffacilityinHainanprovincesHaikoucityovertheyears,andplanstoexpanditstourismbusiness,inadditiontoitsrealestate,financialandmedicalinvolvement."Thefull-oncooperationistodevelopasoundindustrialchainmodelfeaturingtravelagency,scenicspot,hotelandtransportation,"saysWangGaochao,chairmanofthecompany.

AstillfromthefilmOceans8[Photo/Mtime]20thCenturyFoxssuperherofilmDeadpool2cameinthirdplacewithanestimated$,pushingitsNorthAmericancumeto$ssupernaturalhorrorfilmHereditaryopenedinfourthplacewithanestimated$lowingthedeathoftheirreclusivegrandmother."Notforthefaintofheart,Hereditarypushesthelimitsofhorrorandpsychologicalterrortoaterrifyinglevelofintensity,"ssuperherofilmAvengers:InfinityWarfinishedfifthwithanestimated$$$1,998millionworldwidethroughSunday.

  ParticipantsworkoutonpaddleboardsduringatriptoNorthLakeTahoe,,withtravelersplanningtripswithagoalofimprovingtheirhealthandwell-being.[Photo/Agencies]FORTLAUDERDALE,Florida-Itsonethingwhenhotelsopenfitnesscenters,snewHudsonYardsneigarybikesandrentworkoutclothes-butsforagingforyourownmedicinalherbsinPeru,cyclingacrosstheCaliforniacoastlineorspendingseveralthousanddollarstoworkoutalongsidecelebtrainerTracyAndersoninAspen,Colorado,wellnesstouristsmade691milliontripsin2015,,wellnessvacationsstraddledbetweenstarvation-sty,$563billionin2015,upfrom$489billionin2013,$,they,,likeayogameditationretreatorsurfcamp,toconnectwithothersandrevitalizethemselves,expertssay."(Fitnesshas)gonefrombeinganactivityto,now,itsapurpose,"saysMarshalCohen,ananalystforthetrendgroupNPD."Thatrebuildingmemories,andthephotoswereclickingonourphonesandpostingonsocialmediaarethefruitsofourlabor."TheCurtainBluffresortinAntigualaunchedanewwellnessconciergewhereguestscanmeetwiththeteamatnoextrachargetodesigntheirownfitnessprogram,sresortinPhuket,Thailand,createdfourwellnessimmersions,whereguestscanfocusonfitness,weightloss,di,analternativestress-reductiontherapy,,,,inpartnershipwithO,TheOprahMagazine,,forexample,andyoumightendupdoingyogaonacoconutplantationinKoSamui,Thailand,oroutdoortaichiinMarseille,France,withaviewoftheseaononesideandapalaceontheother."Weareseeing(cruise)linesofeveryilkandsizeembracehealthyeating,fitness,allsortsofpositive,newkindsofapproachestoyogaandthatkindofthing,""athleisure",abohemianlinepopularwithyogis,sretreatsstartedafewyearsagowhereparticipantscanexercisean,whoisGwynethPaltrowsbusinesspartnerandthetrainerwhoshapesJenniferLopezsfamousbooty,strainerAnnaKaiserleadsafewtripsayear,ldout,sguestspaybetween$2,000and$6,000forhercatharticworkoutswithoptionsforb,000wellnessloversattendeduber-popularWanderlustfestivalsacrossNorthAmericalastyear,partakingineverythingfromyogaandmeditationtostand-uppaddleboardingandspinninginspotslikeOahu,Hawaii,andSquawValley,

  Thisvasegatheringdustinaloftturnedouttobeahugely-importantChinesevasewhichhassoldafteratenseauctionroombattle.[Photo/VCG]UnsuspectingownersbroughtthetreasureinashoeboxforvaluationAlong-forgottenandrareChineseim($19million)atSothebyhevase-decoratedwithdeerandcranes-at500,ssaidthevaseisofexceptionalrarityandtheonlyknownexampleofitskind,bearingamarkfromthereignoftheQianlongEmperor(1736-95).The18thcenturyporcelainvasewasfoundbychanceamongdozensofotherpiecesofChinoiseriesinanatticbyitsunsuspectingowners,,SothebysAsianartsexpert,openedtheboxtoexaminethevase,hewasimmediatelystruckbyitsquality."Thisisamajorworkofart,itisasifwehadjustdiscoveredaCaravaggio,"uncleandappearsa,"tookthetrain,thenthemetroandwalkedonfootthroughthedoorsofSothebysandintomyofficewiththevaseinashoeboxprotectedbynewspaper".Headded:"Whensheputtheboxonmydeskandweopeneditwewereallstunnedbythebeautyofthepiece."However,theexactprovenanceoftheitembefore1947cannotbetraced.Despite“Americafirst”policies,PresidentTrump’ialcounsel’sfirstindictments,whichcastashadowovertheWhiteHouse’,TrumpandPresidentXiJinpingwereabletosigndealsworth$253billion,whichmakesthevisittoC,thevisitdemonstratesthat,despiteaninsularforeignpolicy,Trump’se,US-Chinatradeamountedto$579billion,whileTrump’ssingularfocusisonthe$,merchan,ChinaistheUS’ssecond-largestmerchandisetradingpartner,ceislargelytheresultoftheshiftofproductionfacilitiesfromother,,,Chinaisthecenterforglobalsupplychains,whichhasgreatlyloweredUSmultinationals’,SouthKorea,China,VietnamandthePhilippines,,theydidnotwantTrumptoundermineaccesstowhattheyseeasthe$400billionChinesemarket,basedonUSexportsofgoodsandservicestoChina,salesbyUSforeignaffiliatesinChina,,foreigndirectinvestment(FDI)’sfourthlargestservicestradingpartner(at$70billion),third-largestservicesexportmarket,$60billionin2016,butthereisroomforfarmoreasChinaistheworld’,Chinaremainsthesecond-largestforeignholderofUSTreasurysecurities($),whichhelpkeepUSinterestrateslow.

  PaulImondiZhang,whosefatheriscaddyingforhim,,thenclosedoutw,hehaspedigree,recordingtop-10finishesonthetourin2015and2016,whilelastmonthhetiedfor11thattheChangshaChampionshipafterafinal-holeeagle."Ihaveneverbeeninthepositionofleader,"saidZhang,whoturnedproinOctober2014."ImayfeelsomepressureandIwilltrymybesttofindwaysmaketohelpmerelax,""tliketoeatanyfoodduringaround,buthegavemesomefoodwhichgavememoreenergy."Imondialsocardedabogey-freeround,"Onthefrontnine,IthinkthelongestbirdieputtIhadwas6feet,soeverythingelsewaseitheratap-inorinside3feet,sothefrontninewasaveryeasynineholes,”"aidImondi,whoisenjoyingthewidersetupofthecourseinGuilin,oneofChinastoptouristdestinations."salittlebitwiderthanwereusedtoseeing,”"Irawan,27,whomissedthetourslasteventinHaikouduetohiswedding,remainsbogey-freeafter36holesandwasdelightedafterclosingwithabirdietositoneoffthelead."IalwaysfeelbetterwhenImbehindthelead,betterthanhavingthelead,soIdonmjustgoingtosticktoplayingmygame,”"aidIrawan,whosplayinghisfirstfullseasononthetour.",whichkeepsmehappyandjustallowsmetohavefunandenjoythemoment.”"Aftera”frustrating”"rontnine,Saxon,whoteedoffon10,puttogetheraflawlessbackninewhichstartedwithaneagleonthepar-5second,followedbytwosetsofback-to-backbirdiesfromNos3and17."Ididntputtgreatonthefrontnine,,Idideverythingprettygood,”"aidSaxon,whosaidplayingpartnerJinmotivatedhim."ItsawesomethatJinisplayingwell,”"aidSaxon,"It”"Everytournamentonthisyear,tionaldevelopmentaltour,followinginthefootstepsofPGATourLatinoamericaandtheMackenzieTour–,PGATourSeries-ChinaplayershavereceivedOfficialWorldGolfRankingpointsfortopfinishesatofficialtournaments.

  PaulImondiZhang,whosefatheriscaddyingforhim,,thenclosedoutw,hehaspedigree,recordingtop-10finishesonthetourin2015and2016,whilelastmonthhetiedfor11thattheChangshaChampionshipafterafinal-holeeagle."Ihaveneverbeeninthepositionofleader,"saidZhang,whoturnedproinOctober2014."ImayfeelsomepressureandIwilltrymybesttofindwaysmaketohelpmerelax,""tliketoeatanyfoodduringaround,buthegavemesomefoodwhichgavememoreenergy."Imondialsocardedabogey-freeround,"Onthefrontnine,IthinkthelongestbirdieputtIhadwas6feet,soeverythingelsewaseitheratap-inorinside3feet,sothefrontninewasaveryeasynineholes,”"aidImondi,whoisenjoyingthewidersetupofthecourseinGuilin,oneofChinastoptouristdestinations."salittlebitwiderthanwereusedtoseeing,”"Irawan,27,whomissedthetourslasteventinHaikouduetohiswedding,remainsbogey-freeafter36holesandwasdelightedafterclosingwithabirdietositoneoffthelead."IalwaysfeelbetterwhenImbehindthelead,betterthanhavingthelead,soIdonmjustgoingtosticktoplayingmygame,”"aidIrawan,whosplayinghisfirstfullseasononthetour.",whichkeepsmehappyandjustallowsmetohavefunandenjoythemoment.”"Aftera”frustrating”"rontnine,Saxon,whoteedoffon10,puttogetheraflawlessbackninewhichstartedwithaneagleonthepar-5second,followedbytwosetsofback-to-backbirdiesfromNos3and17."Ididntputtgreatonthefrontnine,,Idideverythingprettygood,”"aidSaxon,whosaidplayingpartnerJinmotivatedhim."ItsawesomethatJinisplayingwell,”"aidSaxon,"It”"Everytournamentonthisyear,tionaldevelopmentaltour,followinginthefootstepsofPGATourLatinoamericaandtheMackenzieTour–,PGATourSeries-ChinaplayershavereceivedOfficialWorldGolfRankingpointsfortopfinishesatofficialtournaments.ThebullettrainrunsoverabridgeonDec16.[Photo/Xinhua]At7:50am,December26,2015,,,,lityofChongqingandSichuansprovincialcapital,,ithaspu,astatementwasreleasedsayingChinawillmakemoreefforttoimprovecityclustersintheeasternregion,and,Chinaplansonbuildingfivestate-levelcityclustersinYangtzeRiverDelta,PearlRiverDelta,Beijing-Tianjin-Hebeiprovince,banizationdevelopmentofthe“wildwest”.ItisalsoexpectedtobecomethefourthpillarofChinaseconomy,followingtheYangtzeRiverDelta,,,thisareaprovidesalargelaborforce,avastuntappedmarket,,acitywithapopulationof30millionpeople,isthefourthmunicipalityunderthedirectleadershipofthecentralgovernmentafterBeijing,Shanghai,,,themunicipali,Chongqing,ametropolitanintheWestSichuanPlains,ha,Chengdumakesitselfabussunderdevelopedwestregion,thiscityclusterisofgreatsignificanceinthecountry,itisnotaneasytasktocoordinatethepeopleinthisgrandmissionduetoyearsofcompetitiontobecomeWestChina

  ChrisColeman(right),formerWales,SunderlandandFulhamcoach,hastakenoverasthenewmanagerofChineseSuperLeagueoutfitHebeiChinaFortune.[Photo/TheClubsWebsite]FormerWalesbossChrisColemanisthenewmanagerofChineseSuperLeaguesideHebeiChinaFortune,,wholedtheWelshnationalteamtothesemifinaloftheEuropeanChampionshipin2016,takesthereinsfromChileanmanagerManuelPellegrini,oqualifyfortheWorldCup,andtookchargeofSunderlandinEnglandssecond-tierdivision,(right),formerWales,SunderlandandFulhamcoach,hastakesWebsiteHavinginheritedastrugglingside,hecouldnotsaveSunderlandfromrelegationtoLeagueOne,andwasfiredatthsfirstCSLgameinchargewillbeonJuly18atDalianYifangaftertheleagueresumesfollowingthemidseasonbreak."WewelcomeMrColemansarrivalandexpecthimtobringnewideastotheteamandhelptheteamreachitstargetforthisseason,"gdongandJiangZhipengaswellasfourforeignstars:formerBarcelonamidfielderJavierMascherano,ex-ParisSaint-GermainattackerEzequielLavezzi,bothofArgentina,formerArsenalstrikerGervinhoofCotedIvoire,nwhenPellegriniguidedittofourthplace,"relegationspecialist",whismovetoChinaischieflymotivatedbymoney,afterEnglishmediareportedhewillearn$atSunderland."TheappointmentofChrisColemanissomethingofasurprise,especiallyashehasrecentlypresidedovertherelegationofSunderland,"saidSimonChadwick,aprofessorofsportsenterpriseatSalfordUniversity."Inmanyways,,thisisthechancetoworkwithacoachwhohasrecentlybeencoachinginternationalstars,suchas(RealMadrids)GarethBale."WithColemanincharge,,thisisashrewd,potentiallyconstructivemovewhich,ifColemancanre-establishhimselfatclublevel,couldformthebasisforahighlyproductivepartnership."Coleman,adefender,playedforSwanseaCity,CrystalPalace,BlackburnRoversandFulham,aswellaswinning32capsforWales,befoFulhamin2003,a,wherehefamouslyturneduplateforanewsconferenceafteranightoutandinitiallyblamedabrokenwashingmachineforhistardiness,,andby2015hehadsteeredthecountrytoitshighesteverpositionofeighth,withasquadincludingBaleandArsenal,Walesfirstmajortournamentsince1958,wheretheDragonstoppedtheirgroupandreachedthesemifinalbeforelosingtoeventualchampionPortugal.

  ChengYonghua,ChineseAmbassadortoJapan,speaksduringanewsconferenceatJapanNationalPressClubinTokyo,July23,2015.[Photo/VCG]ThetripwillbefirstonebyaChinesepremierineightyearsTOKYO-ChinesePremierLiKeqiangsupcomingtriptoJapanisofgreatsignificancetobilateralrelationsaswellasregionalcooperationandprosperity,meetingofChina,JapanandtheRepublicofKorea,,theambassadorsaid,isexpectedtofurtherconsolidatethewarming-upyearsofthisdecade,whichseriouslydamagedthepoliticalmutualtrustandpracticalinterestsofthetwocountries,,thetwosidesreachedafour-pointagreementthatreaffirmedtheprinciplesforthemtoproperlyhandlehistorical,territorialandotherissues,andbilateraltiesbegantoimprove,,Chengsaid,hasfurtherincreasedsinceChinesePresidentXiJinpingmetinMay2017inBeijingwithToshihiroNikai,secretary-generaloftheLiberalDemocraticParty,wholedtheJap-JapanTreatyofPeaceandFriendship,ChengsaidthetwoneighandJapanshouldsticktopeace,friendshipandcooperation,whichisnotonlythesolecorrectchoiceforthetwosides,butalsothecommonaspirationoftheinternationalcommunity,especiallytheAsiancountries,,bilateralexchangesan,bilateraltradereturnedtoabovethe$300billionlevelandpersonnelexchangesincreasedtoarecordhighof10million,,ChinaandJapanaresharingmoreandmorecommoninterests,saidCheng,addingthatastwoimportantplayersinAsiaandbeyond,thetwocountriesalsoshoulderthecommonresponsibili,hesuggested,shouldseizetheopportunitytostrengthenexchangesandcooperationinvariousfields,continuouslyexpandtheircommoninterests,,LisofficialvisittoJapanandattendanceatthetrilateralleadersmeetingareworthlookingforwardto,theambassadorsaid."Ibelievethatwiththejointeffortsofthetwosides,thisvisitwillhelpbringChina-Japanrelationsbacktotherighttracksothattheycanrealizesoundandstabledevelopment,"

  AnAfghanshopkeeperworksonhislaptopathisonlinestoreinKabul,AfghanistanonJune4.[Photo/Agencies]KABUL-ShoppersintheAfghancapitalaregoingonlineforeverythingfromfashiontofurnituretoavoidbombattacksandsexualharassment,withdozensofdsofpeoplethisyearands,,,,sellgoodsrangingfromcosmetics,computers,kitchenwareandfurnituretocars,,"goodexperience"inacountryatwar,withUNfiguresputtingthoseunder25atmorethan60percentofthepopulation,thevastmajorityofthementhusiasticsmartphoneusers."Whodaresgooutshoppingthesedays"shesaid."Iamsuretherearesomepeople,butformeithasalwaysbeendifficult...Fearsofanexplosion,anattackandthemostcommonthing,harassment,followmelikemyshadow."Esmatullah,27,ownerofAfghanMart,whichhesetupjustoverayearago,hasashopwith500,000afghanis($7,000)worthofgoods.","hesaid,ad,hesaid,wassecualleys,sometimesthroughpeopleshomesandgardens,toavoidthethreatandtrafficofmajorroadsandintersections."WehaveseenmorebombblastsinKabulthatdelayedourdeliveryservices,"Esmatullahsaid."Whenthathappens,westopdeliveringinthatdirectionorthatpartofthecity.",thereisabadcultureofstreetharassmentthatunfortunatelyourwomenfaceincities."Goodsaredeliveredbymotorcycleorpublictransportwherepossibleandthedeliverymengetpaidupto8,s"unique"foracountryatwarformorethanfourdecades,withabout50companiesinbusiness,mostofthemunlicensed."ThecultureofonlinestoresonlystartedtwoyearsagoinKabulandrightnowmorethan20onlinestoreshavealicensetotrade-therearemanymorethathaveyettogettheirlicenseandweencouragethemtocomeforward."Aroundtheworld,"ReutersHainan,Chinassouthernmostprovince,hasestablishedanewbenchmarkareatopromotedevelopmentoftheChina(Hainan)PilotFreeTradeZone,tswiththreeenterprisesonMay2,aimingtodevelopindustrialchainenterprisesatthe100billionyuan($)oritiesinHainanprovinceonSundayarethetoughestbothnationwideandinthetropicalisland,theislandoffChinassoutherncoast,wouldevokementalimagesofHainanAirlines,gianttropical-themedhotelcompounds,coconutmilkandmigrantsfromChinasopening-uppolicy,whichisalreadyencouragingtheworldsbigcompaniesandinvestorstoredrawtheirstrategies,otonlyboostSouthChinasdevelopment,butalsocatalyzeeconomicgrowthintheAsia-Pacificregionandtherestoftheworld,saidoneofthenation,XishaIslands,ZhongshaIslandsandNanshaIslands,aswellasmorethan240isletsandthesurroundingseaterritories.

  

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科研团队回应滴血测癌:测的是患癌风险,可辅助临床诊断

2019-08-23 07:53 | 人民日报 | 手机看国搜 | 打印 | 收藏 |评论 | 扫描到手机
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核心提示:一篇一滴血可测癌症的文章最近网上很火。一时间,“滴血测癌”这一提法热度飙升。记者得到了罗永章团队的回复:测的不是癌,测的是患癌风险。

一篇《重大突破!一滴血可测癌症 已被批准临床使用》的文章最近网上很火。文章提到:“清华大学生命科学学院罗永章团队自主研发出了一种专门检测热休克蛋白90α的试剂盒。患者只需取一滴血,即可用于癌症病情监测和治疗效果评价”。一时间,“滴血测癌”这一提法热度飙升。这事靠谱吗?求证栏目记者得到了罗永章团队的回复:测的不是癌,测的是患癌风险。

一滴血能测出癌症吗?

通过2.5微升血检测肿瘤标志物,以检测患癌风险、进行病情监测和疗效评价等

“滴血测癌”这个热词其实不新。早在2013年,罗永章团队宣布,在国际上首次发现热休克蛋白90α为一个全新的肿瘤标志物,并自主研发出试剂盒。当时就被媒体误读为“一滴血检测肿瘤”,今年再度翻出来热炒,原因在于试剂盒最近获得欧盟的准入许可。

罗永章团队回应说,“滴血测癌”作为媒体给出的概括,不够准确。该科研成果是通过中国自主研发的新肿瘤标志物来检测患癌的风险,并可对癌症患者进行病情监测和疗效评价,也是临床诊断和预后的重要辅助依据。

据了解,实际检测只需要2.5微升血,一滴血约有50微升,是2.5微升的20倍,所以“一滴血”当然够。罗永章团队认为,不必纠结字眼,如果说法准确点,应叫检测患癌的风险。该项检测相当于给医生和患者多了一个比现有肿瘤标志物更好的工具。

罗永章团队介绍,该项肿瘤标志物检测是基于酶联免疫法进行的,检测时将稀释的血和不同浓度的校准液同时分别加入检测板中,形成了一个夹心反应,最后加入显色系统,就可以通过颜色的变化经专业仪器计算出相关数值,来定量检测人血中天然热休克蛋白90α的含量。

这项研究突破在哪?

此全新肿瘤标志物及试剂盒为我国自主发现、自主研发,从科研走到临床表现抢眼

这项研究亮点在哪儿?还得从肿瘤标志物说起。

肿瘤标志物是由恶性肿瘤细胞异常产生的物质,或是肿瘤刺激人体产生的物质,一定程度上可以反映出肿瘤的发生、发展。通过肿瘤标志物检测,可以对人体癌变提供指示和判断,监测肿瘤的进展和预后。

研究的突破在于,这个标志物是由我国科研团队首次在世界上发现并且定义的,而且是第一个获得批准可用于临床的。

罗永章团队表示,该项研究与过往的研究有着本质的区别,首次证明了人血浆热休克蛋白90α是一个全新的肿瘤标志物,并自主研发一种专门检测热休克蛋白90α的定量检测试剂盒,只需患者一滴血的采血量,即可用于癌症病情监测和治疗效果评价,重要的是从科研走到临床。

目前,我国自主研发的热休克蛋白定量检测试剂盒已通过临床试验验证,获得国家第三类也就是最高类别的医疗器械证书,并通过欧盟CE认证,获准进入中国和欧盟市场。国家食品药品监督管理总局将其批准用于肺癌患者和肝癌患者的病情监测和疗效评价。这是热休克蛋白90α被发现24年来,全球第一个获准将其用于临床的产品。

值得一提的是,这一全新的肿瘤标志物在肺癌和肝癌临床试验中,灵敏度和准确度超过了现有的常用肺癌和肝癌标志物。在肝癌的检测中,灵敏度达到了93%,比常用的肝癌标志物甲胎蛋白(AFP)灵敏度高出近一倍。团队研究成果为医生诊疗增加了有价值的信息和判断依据,有助于提高我国癌症的诊疗水平。

临床作用有多大?

可辅助临床诊断,但是不是肿瘤还得看病理学诊断

需要强调的是,究竟是不是癌症,不是试剂盒说了算,而是病理学诊断说了算。临床使用的血液检测有将近20种肿瘤标志物,但并不是说肿瘤标志物高,就一定是癌症,也无法靠一种血液标志物百分百地诊断肿瘤。

北京体检中心首席专家杨建国表示,滴血检测只是一种患癌的风险提示。如果热休克蛋白90α持续在异常高位或者持续异常升高,那么预示着患癌风险加大。

“滴血检测还可以帮助临床医生判断患者疗效。”杨建国说,患者治疗一段时间后,医生通过肿瘤标志物来观察治疗的效果,判断患者是否有复发。当然,不能太依赖这项检测,因为肿瘤标志物存在非特异性,一些正常组织或良性肿瘤以及炎症反应也可能使肿瘤标记升高,让测试结果出现假阳性。

业内人士认为,热休克蛋白90α检测技术进入临床并成功运用,为肿瘤学诊断打开一扇窗,是肿瘤患者一大福音。

杨建国说,各种检测手段都是为临床医生做出最合理的判断提供侧面的检测信息,连大家熟知的CT检测也只是影像学诊断,不能作为癌症确诊的依据。

(原题为《测的是患癌风险》王君平/文)(完)

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